Clay Wright
- Research: Plant Synthetic Biology
Education
Ph.D., Chemical and Biomolecular Engineering, Johns Hopkins University, 2014
B.S., Chemical and Biomolecular Engineering, North Carolina State University, 2008
Experience
April 2014 – August 2018 - Postdoctoral Fellow, Departments of Biology and Electrical Engineering, University of Washington, Seattle WA
January 2013 – April 2014 - Co-founder, Revolve Biotech Inc., Baltimore MD
January 2013 – July 2013 – Engineering Consultant, Novocor Medical Systems, Chapel Hill NC
January 2005 – January 2007 - Molecular Pharmacology Research Assistant, Inspire Pharmaceuticals Inc., Durham NC
Selected Major Awards
- 2014 – 2017 - NSF Postdoctoral Research Fellowship at the Intersection of Biology, Mathematical and Physical Sciences
- 2010 – 2014 - NSF Graduate Research Fellowship
Teaching Activities
University of Washington, School of Aquatic and Fisheries Sciences, Introduction to R Programming (FISH 552) and Advanced R Programming (FISH 553) for Natural Scientists
Program Focus
My research group aims to accelerate the engineering of biological systems, from proteins and yeast for diagnostics, biosensors, and catalysts, to plants in the sense of agricultural crops and biomanufacturing facilities. We build both understanding of biology as well as novel functions using a combination of systems and synthetic biology techniques. Our roots are in protein engineering, synthetic biology, lab automation, and yeast and Arabidopsis genetics, but we explore and engineer many aspects of biology with a translational focus on improving sustainability and global public and environmental health.
Selected Recent Publications
Wright RC, Zahler ML*, Gerben SL*, Nemhauser JL (2017) Insights into the Evolution and Function of Auxin Signaling F-Box Proteins in Arabidopsis thaliana Through Synthetic Analysis of Natural Variants. Genetics 207(2):583-591. doi:10.1534/genetics.117.300092.
Wright RC, Bolten N, Pierre-Jerome E (2017) flowTime: Annotation and analysis of biological dynamical systems using flow cytometry (R-package), January 2017. doi:10.18129/B9.bioc.flowTime.
Pierre-Jerome E, Wright RC, Nemhauser JL (2017) Characterizing Auxin Response Circuits in Saccharomyces cerevisiae by Flow Cytometry. Plant Hormones: Methods and Protocols, Methods in Molecular Biology, vol. 1497, Jürgen Kleine-Vehn and Michael Sauer (eds.). doi:10.1007/978-1-4939-6469-7_22.
Wright RC, Nemhauser JL (2015) New tangles in the auxin signaling web. F1000Prime Rep. 7:19. doi:10.12703/P7-19.
Wright RC, Khakhar A*, Eshleman JR, Ostermeier M (2014) Advancements in the development of HIF-1α-activated protein switches for use in enzyme prodrug therapy. PLoS One. 9(11):e114032. doi:10.1371/journal.pone.0114032.
Kanwar M, Wright RC, Date A, Tullman J, Ostermeier M (2013) Protein switch engineering by domain insertion. Methods in Enzymology. 523:369-88. doi:10.1016/B978-0-12-394292-0.00017-5.
Wright CM, Wright RC, Eshleman JR, Ostermeier M (2011) A protein therapeutic modality founded on molecular regulation. Proc Natl Acad Sci USA. 108(39):16206-11. doi:10.1073/pnas.1102803108.
Featured in Discover Magazine “Top 100 Stories of 2011: #38 Killing Cancer from the Inside” January-February 2012 issue (5 Jan 2012)
Selected Recent Funding
Cracking the code of highly adaptable plant receptor proteins to engineer novel synthetic circuits. NSF PRFB DBI-1402222, 7/14-6/16, Wright: PI. Sponsoring mentors: Jennifer Nemhauser, Biology, University of Washington and Eric Klavins, Electrical Engineering, University of Washington.